What is Homology?
In biology, homology refers to the existence of shared ancestry between a pair of structures, or genes, in different species. This is foundation of evolutionary biology, indicating that organisms share a common ancestor from which these homologous traits have been inherited. And there are two types of homology: orthologs and paralogs. Alignment of multiple sequences are used to indicate which regions of each sequence are homologous.[1]
Fig1: Homologous analysis example
Homology of SLC35A2
Homo sapiens NP_001269580.1
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Mus musculus NP_001077406.1
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Danio rerio NP_001123545.1
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Rana temporaria XP_040180211.1
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Caenorhabditis elegans NP_493723.3
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Arabidopsis thaliana AAT70424.1
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Discussion
The results from BLAST and FASTA revealed that the SLC35A2 protein is well preserved in various species and has numerous similar proteins. Even though, only six of them are mentioned here, there a large amount of SLC35A2 protein could be identified from data bases. Since these species possessing similar proteins, they can be employed as model organisms for SCL35A2 research. The zebrafish is used as model organisms here for future study.
Reference:
[1]Wikipedia contributors. (2024, March 31). Homology (biology). Wikipedia. https://en.wikipedia.org/wiki/Homology_(biology)
Image Reference:
Biorender
https://thedaily.case.edu/gene-editing-improved-with-chemical-process/
https://en.wikipedia.org/wiki/Homology_(biology)#/media/File:Histone_Alignment.png
[1]Wikipedia contributors. (2024, March 31). Homology (biology). Wikipedia. https://en.wikipedia.org/wiki/Homology_(biology)
Image Reference:
Biorender
https://thedaily.case.edu/gene-editing-improved-with-chemical-process/
https://en.wikipedia.org/wiki/Homology_(biology)#/media/File:Histone_Alignment.png